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Spatiotemporal Dynamics of Brain Function During the Natural Course in a Dental Pulp Injury Model
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Abstract
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Spatiotemporal Dynamics of Brain Function During the Natural Course in a Dental Pulp Injury Model
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Novel tyrosinase reporter gene-based PET molecular imaging for in vivo evaluation of neural circuit
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Abstract
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Novel tyrosinase reporter gene-based PET molecular imaging for in vivo evaluation of neural circuit
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[11C]GR103545 PET to elucidate kappa opioid receptor changes under stress and social buffering in the titi monkey
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Abstract
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[11C]GR103545 PET to elucidate kappa opioid receptor changes under stress and social buffering in the titi monkey
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Molecular imaging of vascular inflammation in the rat brain after SRS
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Abstract
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Molecular imaging of vascular inflammation in the rat brain after SRS
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Sex-dependent nonlinear causality patterns of brain aging in healthy population
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Abstract
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Sex-dependent nonlinear causality patterns of brain aging in healthy population
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Evaluation of glymphatic system activity during sleep using diffusion tensor imaging analysis along the perivascular space (DTI-ALPS)
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Abstract
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Evaluation of glymphatic system activity during sleep using diffusion tensor imaging analysis along the perivascular space (DTI-ALPS)
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Brain metabolic alteration in murine models of retinal degeneration using hyperpolarized [1-13C] pyruvate MRI with PHIP-SAH technique.
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Abstract
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Brain metabolic alteration in murine models of retinal degeneration using hyperpolarized [1-13C] pyruvate MRI with PHIP-SAH technique.
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From Synapses to Systems: Unraveling Brain Complexity Through Advanced Imaging
About Lesson
Abstract Body:

Objective Toothache is a common disease that plagues most people and exhibits different characteristics at different clinical stages. This study aims to characterize metabolic changes in the brain and investigate the underlying mechanisms of abnormal affective behavior in the natural process of toothache.Methods: We used positron emission tomography (PET) to study the spatiotemporal patterns of brain function during the natural course of toothache in rats with pulp injury (DPI). Results Glucose metabolism peaked on day 3 and several brain regions gradually decreased after DPI, which was consistent with behavioral and histological results. PET imaging shows that the visual pathway is involved in the regulation of toothache. At the same time, the mood regulation process of toothache is mediated by N-methyl-D-aspartate receptor subunit 2B (NR2B) in the caudal anterior cingulate cortex (cACC).Conclusion The results of this study reveal the spatiotemporal neurological function pattern in the process of toothache, and preliminarily elucidate the role of NR2B in the regulation of toothache-related affective behavior in cACC.

Author

Fei Yan Fei Yu
Shanxi Medical University and Hospital of Stomatology
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