Nanotechnology and Theranostics (Continued)

Molecular Imaging in Nanotechnology and Theranostics

Image-Guided (Precision) Nanomedicine

Twan Lammers, Department of Nanomedicine and Theranostics, RWTH Aachen, Department of Targeted Therapies, University of Twente, Department of Pharmaceutics, Utrecht University, The Netherlands.

This presentation describes nanomedicine and emphasizes imaging’s role in stratifying patients, and in what situations we can use nanomaterials for real clinical translation and better patient benefits. Theranostic nanoparticles combine diagnostic and therapeutic properties within a single formulation. Such agents are highly useful for image-guided drug delivery, which can be employed to individualize and improve interventions, in particular in the case of cancer. By preselecting patients presenting with sufficiently high levels of enhanced permeability retention (EPR), and by excluding those presenting with no or very low EPR-mediated target site accumulation, responders can likely be discriminated from non-responders, thereby providing a theranostic means to personalize nanomedicine treatments.

Nanotechnology: Introduction

Advances in Particles and Polymers

Sanjiv Gambhir, Stanford University, California, USA

Talk Outline:

  • Background on Nanoparticles
  • Unique Solutions Provided by Nanoparticles
  • Features of Nanoparticles
  • Specific Pre-clinical Examples
  • Clinical Studies
  • Future Directions

Targeted particles and polymers

Sjoerd Hak, Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway

Talk Outline:

  • General targeting and imaging strategies
  • Ligand coupling and characterization
  • Application: Reaching the target

Nanotechnology: “Hard” Particles

Gadolinium-based nanoparticles for the treatment of glioblastoma by MRI-guided photodynamic therapy

Eloïse Thomas, University of Lyno, Villeurbanne, France
Talk Outline:

  • Glioblastoma and PDT
  • AGuIX nanoparticles
  • Addition of a peptide (DKPPR)

Monoclonal Antibody Templated Gold Nanoclusters for Fluorescence Imaging of HER2 Receptors

Xin Zhang, Peking University, Beijing Shi, China

Talk Outline:

  • Background: Gold nanoclusters and protein stabilized Au NCs
  • Design and synthesis of Her-Au NCs
  • Imaging of Her-Au NCs

DNA Origami assembled with QD655 and gold nanorod working as a novel nanoprobe for fluorescence and optoacoustic dual imaging modality in 4T1 mammary tumor model

Yang Du, Chinese Academy of Sciences, Beijing, China

Talk Outline:

  • Background: Near Infrared Fluorescence Molecular Imaging
  • DNA based nanostructures
  • DNA Origami-Gold nanorod hybrids for OAI imaging

Image Guided Site-Selective Delivery of Novel Trimodal Optical/MR/X-ray Contrast Nanoconstructs for Colorectal Cancer Liver Metastasis Therapy

Abdul Parchur, Marquette University and Medical College of Wisconsin, Milwaukee, WI, USA
Talk Outline:

  • Photothermal Ablation with Silica-Gold NPs
  • Systemic vs Site-Specific Delivery
  • Photothermal Therapy: Thermal Imaging
  • Dyna-CT Imaging

Nanotechnology: “Soft” Particles

Particles and Polymers for Optical Imaging

Anthony McGoron, Biomedical Engineering, Florida International University, Miami, FL, USA

Learning Objectives:

  • Understand contrast material design driven by imaging modality vs application driven choice of contrast material/imaging modality
  • Introduction into methods for ligand conjugation
  • Understand different kinds of target interactions and their pros and cons for specific applications

Cancer cell membrane coated biomimetic nanoparticles for disrupting cancer cell-stromal cell interaction and priming the immune system

Jiefu Jin, John Hopkins, Baltimore, MD, USA
Talk Outline:

  • RBC membrane camouflaged NPs for detoxification
  • Synthesis and characterization of cancer cell plasma membrane fraction coated PLGA NPs (DDMF+PLGA NPs)
  • In vivo behavior of DDMF+PLGA NPs

Multifunctional near-infrared polymer dots for precise imaging of metastatic lymph nodes

Liqin Xiong, Jiao Tong University, Shanghai, China
Talk outline:

  • Fluroescence polymer dots
  • Overview of the lymphatic system
  • Synthesis and characterization of folate targeted tri-modal polymer dots

Targeted Photodynamic Pre-Treatment: a Novel Strategy to Enhance Tumor Nanoparticle Accumulation

Marta Overchuk, University of Toronto, Canada

Talk outline:

  • Current status of nano-mediated drug delivery for cancer therapy
  • Porphyrin-PSMA targeted particles
  • Enhanced nanoparticle tumor delivery for photoacoustic imaging

Theranostics: Peptide-based Theranostics

Image-guided receptor targeted radionuclide therapy for cancer. Alpha-particle theranostics from academic discovery to clinical use as a small biotech startup

Michael Schultz, The University of Iowa and Viewpoint Molecular Targeting

Talk outline:

  • University start-ups
  • “Academic Entrepreneurism”
  • MC1R targeting
  • Translational realities

Multivalent theranostic nanoprobe for the PSMA-targeted delivery of a therapeutic peptide to prostate cancer

J. Manuel Perez, Cedar Sinai Medical Center, Los Angeles, CA, USA

Talk outline:

  • Prostate specific membrane antigen (PSMA)
  • Folate-conjugated polymeric nanoparticles
  • CT20p, a therapeutic peptide that targets Chaperonin

Theranostics: Small Molecule – based Theranostics

Novel Theranostics Targeting Glutamine Metabolism in Solid Tumors

Michael Schulte, Vanderbilt University, Nashville, TN, USA

Talk Outline:

  • Introduction to glutamine metabolism in oncology
  • ASCT2 function in glutamine transport
  • V-9302, a novel inhibitor of ASCT2

Theranostics: Nanoconstruct – based Theranostics

A novel theranostic strategy for MMP-14 expressing glioblastomas impacts survival

Suchismita Mohanty, Stanford University, Stanford, CA, USA

Talk Outline:

  • Challenges in Glioblastoma therapy
  • Theranostic nanoparticles: Concept and design
  • Matrix metalloproteinase-14 function
  • In vivo behavior of theranostic strategy

Ultrasound-triggered micro-to-nano conversion: Exploring porphyrin-bubble theranostic potential beyond the vasculature

Carly Pellow, University of Toronto, Toronto, Canada

Talk Outline:

  • Nanomedicine and the Tumor Microvasculature
  • Microbubbles and Ultrasound-Triggered Bio-effects
  • Porphyrin Microbubbles
  • In vivo protocols and outcomes