Nanotechnology and Theranostics (Continued)

Molecular Imaging in Nanotechnology and Theranostics

Image-Guided (Precision) Nanomedicine

Twan Lammers, Department of Nanomedicine and Theranostics, RWTH Aachen, Department of Targeted Therapies, University of Twente, Department of Pharmaceutics, Utrecht University, The Netherlands.

This presentation describes nanomedicine and emphasizes imaging’s role in stratifying patients, and in what situations we can use nanomaterials for real clinical translation and better patient benefits. Theranostic nanoparticles combine diagnostic and therapeutic properties within a single formulation. Such agents are highly useful for image-guided drug delivery, which can be employed to individualize and improve interventions, in particular in the case of cancer. By preselecting patients presenting with sufficiently high levels of enhanced permeability retention (EPR), and by excluding those presenting with no or very low EPR-mediated target site accumulation, responders can likely be discriminated from non-responders, thereby providing a theranostic means to personalize nanomedicine treatments.

Nanotechnology: Introduction

Advances in Particles and Polymers

Sanjiv Gambhir, Stanford University, California, USA

Talk Outline:

Background on Nanoparticles
Unique Solutions Provided by Nanoparticles
Features of Nanoparticles
Specific Pre-clinical Examples
Clinical Studies
Future Directions

Targeted particles and polymers

Sjoerd Hak, Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway

Talk Outline:

General targeting and imaging strategies
Ligand coupling and characterization
Application: Reaching the target

Nanotechnology: “Hard” Particles

Gadolinium-based nanoparticles for the treatment of glioblastoma by MRI-guided photodynamic therapy

Eloïse Thomas, University of Lyno, Villeurbanne, France
Talk Outline:

Glioblastoma and PDT
AGuIX nanoparticles
Addition of a peptide (DKPPR)

Monoclonal Antibody Templated Gold Nanoclusters for Fluorescence Imaging of HER2 Receptors

Xin Zhang, Peking University, Beijing Shi, China

Talk Outline:

Background: Gold nanoclusters and protein stabilized Au NCs
Design and synthesis of Her-Au NCs
Imaging of Her-Au NCs

DNA Origami assembled with QD655 and gold nanorod working as a novel nanoprobe for fluorescence and optoacoustic dual imaging modality in 4T1 mammary tumor model

Yang Du, Chinese Academy of Sciences, Beijing, China

Talk Outline:

Background: Near Infrared Fluorescence Molecular Imaging
DNA based nanostructures
DNA Origami-Gold nanorod hybrids for OAI imaging

Image Guided Site-Selective Delivery of Novel Trimodal Optical/MR/X-ray Contrast Nanoconstructs for Colorectal Cancer Liver Metastasis Therapy

Abdul Parchur, Marquette University and Medical College of Wisconsin, Milwaukee, WI, USA
Talk Outline:

Photothermal Ablation with Silica-Gold NPs
Systemic vs Site-Specific Delivery
Photothermal Therapy: Thermal Imaging
Dyna-CT Imaging

Nanotechnology: “Soft” Particles

Particles and Polymers for Optical Imaging

Anthony McGoron, Biomedical Engineering, Florida International University, Miami, FL, USA

Learning Objectives:

Understand contrast material design driven by imaging modality vs application driven choice of contrast material/imaging modality
Introduction into methods for ligand conjugation
Understand different kinds of target interactions and their pros and cons for specific applications

Cancer cell membrane coated biomimetic nanoparticles for disrupting cancer cell-stromal cell interaction and priming the immune system

Jiefu Jin, John Hopkins, Baltimore, MD, USA
Talk Outline:

RBC membrane camouflaged NPs for detoxification
Synthesis and characterization of cancer cell plasma membrane fraction coated PLGA NPs (DDMF+PLGA NPs)
In vivo behavior of DDMF+PLGA NPs