Molecular Imaging in Nanotechnology and Theranostics
Image-Guided (Precision) Nanomedicine
Twan Lammers, Department of Nanomedicine and Theranostics, RWTH Aachen, Department of Targeted Therapies, University of Twente, Department of Pharmaceutics, Utrecht University, The Netherlands.
This presentation describes nanomedicine and emphasizes imaging’s role in stratifying patients, and in what situations we can use nanomaterials for real clinical translation and better patient benefits. Theranostic nanoparticles combine diagnostic and therapeutic properties within a single formulation. Such agents are highly useful for image-guided drug delivery, which can be employed to individualize and improve interventions, in particular in the case of cancer. By preselecting patients presenting with sufficiently high levels of enhanced permeability retention (EPR), and by excluding those presenting with no or very low EPR-mediated target site accumulation, responders can likely be discriminated from non-responders, thereby providing a theranostic means to personalize nanomedicine treatments.
Nanotechnology: Introduction
Advances in Particles and Polymers
Sanjiv Gambhir, Stanford University, California, USA
Talk Outline:
- Background on Nanoparticles
- Unique Solutions Provided by Nanoparticles
- Features of Nanoparticles
- Specific Pre-clinical Examples
- Clinical Studies
- Future Directions
Targeted particles and polymers
Sjoerd Hak, Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
Talk Outline:
- General targeting and imaging strategies
- Ligand coupling and characterization
- Application: Reaching the target
Nanotechnology: “Hard” Particles
Gadolinium-based nanoparticles for the treatment of glioblastoma by MRI-guided photodynamic therapy
Eloïse Thomas, University of Lyno, Villeurbanne, France
Talk Outline:
- Glioblastoma and PDT
- AGuIX nanoparticles
- Addition of a peptide (DKPPR)
Monoclonal Antibody Templated Gold Nanoclusters for Fluorescence Imaging of HER2 Receptors
Xin Zhang, Peking University, Beijing Shi, China
Talk Outline:
- Background: Gold nanoclusters and protein stabilized Au NCs
- Design and synthesis of Her-Au NCs
- Imaging of Her-Au NCs
DNA Origami assembled with QD655 and gold nanorod working as a novel nanoprobe for fluorescence and optoacoustic dual imaging modality in 4T1 mammary tumor model
Yang Du, Chinese Academy of Sciences, Beijing, China
Talk Outline:
- Background: Near Infrared Fluorescence Molecular Imaging
- DNA based nanostructures
- DNA Origami-Gold nanorod hybrids for OAI imaging
Image Guided Site-Selective Delivery of Novel Trimodal Optical/MR/X-ray Contrast Nanoconstructs for Colorectal Cancer Liver Metastasis Therapy
Abdul Parchur, Marquette University and Medical College of Wisconsin, Milwaukee, WI, USA
Talk Outline:
- Photothermal Ablation with Silica-Gold NPs
- Systemic vs Site-Specific Delivery
- Photothermal Therapy: Thermal Imaging
- Dyna-CT Imaging
Nanotechnology: “Soft” Particles
Particles and Polymers for Optical Imaging
Anthony McGoron, Biomedical Engineering, Florida International University, Miami, FL, USA
Learning Objectives:
- Understand contrast material design driven by imaging modality vs application driven choice of contrast material/imaging modality
- Introduction into methods for ligand conjugation
- Understand different kinds of target interactions and their pros and cons for specific applications
Cancer cell membrane coated biomimetic nanoparticles for disrupting cancer cell-stromal cell interaction and priming the immune system
Jiefu Jin, John Hopkins, Baltimore, MD, USA
Talk Outline:
- RBC membrane camouflaged NPs for detoxification
- Synthesis and characterization of cancer cell plasma membrane fraction coated PLGA NPs (DDMF+PLGA NPs)
- In vivo behavior of DDMF+PLGA NPs
Multifunctional near-infrared polymer dots for precise imaging of metastatic lymph nodes
Liqin Xiong, Jiao Tong University, Shanghai, China
Talk outline:
- Fluroescence polymer dots
- Overview of the lymphatic system
- Synthesis and characterization of folate targeted tri-modal polymer dots
Targeted Photodynamic Pre-Treatment: a Novel Strategy to Enhance Tumor Nanoparticle Accumulation
Marta Overchuk, University of Toronto, Canada
Talk outline:
- Current status of nano-mediated drug delivery for cancer therapy
- Porphyrin-PSMA targeted particles
- Enhanced nanoparticle tumor delivery for photoacoustic imaging
Theranostics: Peptide-based Theranostics
Image-guided receptor targeted radionuclide therapy for cancer. Alpha-particle theranostics from academic discovery to clinical use as a small biotech startup
Michael Schultz, The University of Iowa and Viewpoint Molecular Targeting
Talk outline:
- University start-ups
- “Academic Entrepreneurism”
- MC1R targeting
- Translational realities
Multivalent theranostic nanoprobe for the PSMA-targeted delivery of a therapeutic peptide to prostate cancer
J. Manuel Perez, Cedar Sinai Medical Center, Los Angeles, CA, USA
Talk outline:
- Prostate specific membrane antigen (PSMA)
- Folate-conjugated polymeric nanoparticles
- CT20p, a therapeutic peptide that targets Chaperonin
Theranostics: Small Molecule – based Theranostics
Novel Theranostics Targeting Glutamine Metabolism in Solid Tumors
Michael Schulte, Vanderbilt University, Nashville, TN, USA
Talk Outline:
- Introduction to glutamine metabolism in oncology
- ASCT2 function in glutamine transport
- V-9302, a novel inhibitor of ASCT2
Theranostics: Nanoconstruct – based Theranostics
A novel theranostic strategy for MMP-14 expressing glioblastomas impacts survival
Suchismita Mohanty, Stanford University, Stanford, CA, USA
Talk Outline:
- Challenges in Glioblastoma therapy
- Theranostic nanoparticles: Concept and design
- Matrix metalloproteinase-14 function
- In vivo behavior of theranostic strategy
Ultrasound-triggered micro-to-nano conversion: Exploring porphyrin-bubble theranostic potential beyond the vasculature
Carly Pellow, University of Toronto, Toronto, Canada
Talk Outline:
- Nanomedicine and the Tumor Microvasculature
- Microbubbles and Ultrasound-Triggered Bio-effects
- Porphyrin Microbubbles
- In vivo protocols and outcomes