Talk Title:
Imaging Response Assessment in Therapeutic Clinical Trials

Talk Summary:
This presentation will focus on the molecular imaging approaches that are used in clinical trials to evaluate novel investigational therapeutics including radiopharmaceuticals. It will first outline the major approaches used with conventional anatomic imaging and highlight their current limitations. It will then describe the molecular imaging approaches that can be used to enhance imaging response assessments. Efforts to standardize imaging and harmonize quantitative results in multicenter trials will be described. Lastly, advanced quantitative approaches including AI-based software will be demonstrated.

Presenter Biography:
Jeffrey Yap, PhD is medical physicist and Research Professor of Radiology and Imaging Sciences at the University of Utah. He is also the Director of the Center for Quantitative Cancer Imaging and Theranostics at the Huntsman Cancer Institute. His research interests are the use of imaging biomarkers in cancer therapy clinical trials and the development of radiopharmaceuticals using preclinical imaging with SPECT/CT and PET/MRI.

Author
Jeffrey T. Yap
University of Utah Huntsman Cancer Institute