Nanoparticles: “Hard” Nanoparticles

Nanoparticles synthesized from metallic elements are typically classified as “hard” due to their rigid structure and in medical imaging, they serve as contrast agents—detectable with multiple modalities simultaneously—giving rise to new techniques for the ever-richer acquisition of molecular information. Metal nanoparticles can also act as radiosensitizers, enhancing the efficacy of radiotherapy, e.g., renally clearable ultrasmall gold nanoclusters with high tumor uptake. In addition, strategies for their synthesis often allow for precise control over size and shape, which determine in vivo behavior and pharmacokinetics. Among the first nanoparticle constructs to allow molecular imaging were superparamagnetic iron oxide nanoparticles (SPIONs), used for contrast generation with magnetic resonance imaging (MRI). Recently, nanoparticles labeled with radiotracers were found to be very promising—particularly in cancer imaging—in preclinical studies because of three major advantages: (1) the EPR effect; (2) high surface-to-volume ratio of the nanoparticles allowing high density radiolabeling either using chelators (such as DOTA), chelator-free strategies, or intrinsic labeling during synthesis; and (3) complementary multimodal imaging.


Advances in Particles and Polymers

Sanjiv Gambhir, Stanford University, California, USA

Talk Outline:

  • Background on Nanoparticles
  • Unique Solutions Provided by Nanoparticles
  • Features of Nanoparticles
  • Specific Pre-clinical Examples
  • Clinical Studies
  • Future Directions


Gadolinium-based nanoparticles for the treatment of glioblastoma by MRI-guided photodynamic therapy

Eloïse Thomas, University of Lyno, Villeurbanne, France

Talk Outline:

  • Glioblastoma and PDT
  • AGuIX nanoparticles
  • Addition of a peptide (DKPPR)


Monoclonal Antibody Templated Gold Nanoclusters for Fluorescence Imaging of HER2 Receptors

Xin Zhang, Peking University, Beijing Shi, China

Talk Outline:

  • Background: Gold nanoclusters and protein stabilized Au NCs
  • Design and synthesis of Her-Au NCs
  • Imaging of Her-Au NCs


DNA Origami assembled with QD655 and gold nanorod working as a novel nanoprobe for fluorescence and optoacoustic dual imaging modality in 4T1 mammary tumor model

Yang Du, Chinese Academy of Sciences, Beijing, China

Talk Outline:

  • Background: Near Infrared Fluorescence Molecular Imaging
  • DNA based nanostructures
  • DNA Origami-Gold nanorod hybrids for OAI imaging


Image Guided Site-Selective Delivery of Novel Trimodal Optical/MR/X-ray Contrast Nanoconstructs for Colorectal Cancer Liver Metastasis Therapy

Abdul Parchur, Marquette University and Medical College of Wisconsin, Milwaukee, WI, USA

Talk Outline:

  • Photothermal Ablation with Silica-Gold NPs
  • Systemic vs Site-Specific Delivery
  • Photothermal Therapy: Thermal Imaging
  • Dyna-CT Imaging

Home Widget 3

This is your third home widget box. To edit please go to Appearance > Widgets and choose 8th widget from the top in area 8 called Home Widget 3. Title is also manageable from widgets as well.